A Novel Porcine Model for Chemically Inducible Crohn’s-Like Reaction

Background: New animal models provide insights into the
pathogenesis of different types of inflammatory bowel disease
as well as novel pathways for new therapeutic options. However,
the scarcity of large animal models hinders the research and
development of new surgical procedures and technological
devices in inflammatory bowel disease surgery. Common small
animal inducible models involve chemical agents that result in
the development of acute intestinal inflammation.
Objectives: To assess a novel method for the induction of
Crohn’s-like colitis using intramural injection of sclerosants in
a porcine model.

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