STZ single and multi-systemic injection or selective injection to the pancreatic blood supply by Cath procedure. 1 month to 1 year diabetic pig model. The pig is useful as a model for human physiology and pathophysiology, because many organ systems resemble those of the human. Of special interest for the study of diabetes are the similarities to humans found in the clinical chemistry, nutrition and gastrointestinal tract, pancreas development morphology, and metabolism. These characteristics make swine an interesting species for studies of metabolic abnormalities in diabetes.
The model is relevant to efficacy diabetic and long-term diabetic complications drugs, medical device and combined products.