Metabolic Diabetes

  • Diabetes, Obesity, Diabetes related implantable devices and drugs.
  • Evaluation of safety and efficacy of metabolic drugs and medical devices.
  • Translational large animal disease model (pig) for long-term Type I Diabetes.
  • Translational large animal disease model (pig) for obesity.

Desease Models

Pig model for long-term Type I Diabetes.

STZ Induced Type I Diabetes Pig Model

STZ single and multi-systemic injection or selective injection to the pancreatic blood supply by Cath procedure. 1 month to 1 year diabetic pig model. The pig is useful as a model for human physiology and pathophysiology, because many organ systems resemble those of the human. Of special interest for the study of diabetes are the similarities to humans found in the clinical chemistry, nutrition and gastrointestinal tract, pancreas development morphology, and metabolism. These characteristics make swine an interesting species for studies of metabolic abnormalities in diabetes.

The model is relevant to efficacy diabetic and long-term diabetic complications drugs, medical device and combined products.

Pig model for post- surgical adhesion (peritoneal cavity)

A midline laparotomy is performed in order to expose the cecum. A surface on the peritoneum and on the cecum is gently abraded. The abdominal sidewall is sutured in order to create an ischemic area. Talc powder is spread on the abraded surfaces of cecum and peritoneum. Few days after the procedure the abdomen is opened carefully and cecum- peritoneum procedure is exposed and evaluated.

The advantage of the pig’s adhesions model is the organ size that are compatible with human organs size.  This model is an aggressive model for postsurgical adhesions suitable for evaluations of surgical anti- adhesion products.

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