How to choose a large animal model for preclinical studies – Sheep models In our previous blog we discussed Swine models and the many factors involved in choosing the most suitable animal model including regulatory standards and ethics, the suitability of specific species to match the product specialty, anatomical differences between humans and animals, etc. Lahav CRO specializes in pre-clinical testing with large animal models including swine and sheep. Here we will discuss the characteristics of various sheep models and briefly explain their suitability for various pre-clinical studies.   Sheep as animal models – advantages There are many reasons for

Sheep as an animal model for orthopedic studies – The suitability of sheep for orthopedic models. In our previous blog, we discussed how to choose a large animal for preclinical studies and focused on Sheep models. Here we will delve in deeper and discuss ‘why’ and ‘what’ makes sheep models suitable for preclinical studies, especially in the field of orthopedics.  Comparative anatomy – spine While it might not seem obvious, the anatomical bone structure of sheep is indeed similar to human bone structure, especially the spine. Given that sheep do not stand in an upright position (vertical posture), the visual

When developing a medical device or pharmaceutical, we often jump to thoughts of getting approval from a regulatory authority (e.g., FDA or CE). However, in order to get that approval and be able to sell your product, everything leading up to the request for approval has to be objectively defined complying with the most strict reliability standards. This is where Good Laboratory Practice Comes in. Without GLP-compliance, receiving approval based on your pre-clinical trials, will be very hard to achieve.   If this sounds intimidating, it should. That is why we are writing this discussion and that is also why it