Pain Management

  • Neuropathic pain and post‐operative pain.
  • Evaluation of safety and efficacy of analgesic drugs.
  • Translational large animal disease model (pig) for Neuropathic Pain due to Sciatic Nerve Trauma.
  • Pig incision model of Post‐Operative Pain.

Desease Models

Pig Model of Neuropathic Pain Due To Sciatic Nerve Trauma

The pig is the ideal species for neuropathic pain studies due to the many similarities between pig and human. The large animal model for neuropathic pain presents biopharma companies with the opportunity to study in a more relevant model with fewer limitations on obtaining efficacy and PK data from the same animal. It is ideal for testing local therapies, slow release drug/device combinations as well as systemic therapies aimed at sciatica-related pain in humans. Sciatic nerve injury is created by partial ligation to the sciatic nerves with CFA coated sutures. This method provides a stable and controlled pain for at least 28 days. The model is suitable for a variety of therapies including local therapies to the nerve.

This model was developed together with MD Biosciences Innovalora Ltd.

 

The model has the following advantages:

  • Consistent and reproducible model involving both mechanical injury and inflammation.
  • There is no motor dysfunction avoiding the risk of secondary injury to the foot.
  • The method controls the area of innervation.
  • The pigs are sensitive to the feather test bringing further clinical relevance.
  • Morphine responds similar to what is seen in the clinic

Pig incision model of post‐operative pain.

Management of acute pain related to surgical intervention, termed post‐operative pain or POP, continues to be a major healthcare challenge. While the rat plantar incision model provides valuable data to researchers about the mechanisms mediating POP, the development of topical and localized treatments in small animal models is limited. To help address these issues, we have developed a large animal model of incisional pain.

The pig model of incisional pain can provide an appropriate translational model for validating new topical and localized treatments for POP in humans.

This model was developed together with MD Biosciences Innovalora Ltd.

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